Pancreatic Cancer is a cancer that arise in the pancreas and that, unless controlled at its earliest stages, tends to spread to local tissues and to distant organs. Although surgery can be curative if pancreatic cancer is diagnosed at its very earliest stages, once the cancer has spread to distant organs, the current treatment has some, although limited, efficacy. New treatments are clearly needed.
Cancer associated bone pain
Breast, lung, and prostate cancer, when metastatic, commonly has spread to bones, and when it does, causes very significant pain. The current treatment of the bone pain commonly involves the use of opiates, which can have significant side effects. New non-narcotic treatment of bone pain associated with metastatic breast cancer are needed.
Recurrent/refractory multiple myeloma
Multiple myeloma is a cancer of plasma cells. In multiple myeloma, the overgrowth of plasma cells in the bone marrow can crowd out normal blood-forming cells, leading to failure to produce white and red blood cells and platelets. In addition, myeloma cells produce substances that can cause bone destruction and kidney damage. Although great strides have been made in the treatment of myeloma, relapse is common and the disease tends to become more refractory with each successive line of treatment. New treatments, especially those with lesser side effects, are greatly needed.
Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a blood disorder characterized by uncontrolled proliferation of a type of immature white blood cells called “myeloid cells”, which causes failure of the bone marrow to function properly. AML is the most common type of leukemia in adults.