Pipeline
Azeliragon
- Azeliragon, an oral, small molecule, Phase 2-ready compound, administered once-daily, that inhibits RAGE interactions with its natural ligands, including HMGB1 and S100 proteins produced by cancer cells
- Although azeliragon did not show efficacy in a Phase 3 trial in Alzheimer’s disease, clinical safety data, with over 1500 individuals dosed, indicates high level of safety and tolerability
- There has been extensive demonstration of pre-clinical efficacy of RAGE inhibition in animal models of diverse serious complications of cancer, including cancer bone pain, chemotherapy-induced cognitive impairment, chemotherapy-induced peripheral neuropathy, as well as cancer metastasis.
- RAGE interactions with its ligands has also been implicated in pulmonary and other life-threatening complications of COVID-19 infection.
- Cantex is planning Phase 2 trials in pancreatic cancer, pain associated with bone metastasis, and chemotherapy-induced cognitive impairment.
Dicopp®:
- Blocks mechanisms essential for cancer cell survival
- Phase 1/2 trial in relapsed/refractory myeloma is in progress
- Other cancers that may be amenable to Dicopp® are under consideration.
- Cantex owns issued and pending intellectual property for Dicopp®
- Dicopp® is a 505(b)(2)product
DSTAT:
- Licensed to Chimerix in July 2019. Continued participation in development via Joint Development Committee.
- Key deal terms
- $30 million upfront
- 10 million shares of Chimerix (NASDAQ:CMRX) common stock. We retain these 10 million shares.
- Payments for achieving sales milestones and regulatory approvals totaling $587.5 million
- Tiered double-digit royalties on net sales
- Key deal terms
- Completed randomized Phase 2 study in acute myeloid leukemia (AML) suggested DSTAT + “7+3” improves event-free and relapse-free survival as well as overall survival without additive toxicity
- Phase 3 clinical trial in AML is in progress.
